To get started:

Extract Bash3k-PreAlpha1.zip to any directory. Bash no longer needs to be installed within the game directory.
Open Profilesprofile.ini and edit p_Directory to point to your Skyrim directory.

If you are using a pre-Vista operating system such as Windows XP, you will also need to update p_PluginList to point to the plugins.txt file that Skyrim uses to know which plugins to load.

Save and close profile.ini
Launch Bash3k Pre-Alpha 1 by running: Wrye Bash Launcher.exe